Perancangan Vaksin Berbasis Epitop Sel B Untuk Penyakit Hepatitis B

B CELL EPITOP BASED VACCINE DESIGN FOR HEPATITIS B DISEASE

Authors

  • Erwin Prasetya Toepak Prodi Kimia, Universitas Palangka Raya
  • Rey Kamala Dewi Program Studi Kimia, Universitas Palangka Raya

DOI:

https://doi.org/10.36873/jjms.2021.v3.i2.602

Keywords:

Epitop Sel B, Hepatitis B, Vaccine, Polymerase, In Silico

Abstract

Hepatitis B is a type of disease caused by infection with the hepatitis virus (HBV). HBV is a virus in the Hepadnaviridae family. This viral infection can cause clumping of liver cells, such as cirrhosis and hepatocellular carcinoma which if left untreated can lead to death. HBV itself has a non-structural protein polymerase that plays an important role in its life cycle. This in silico method is economical and effective for the discovery of new drugs by utilizing computer capabilities. In this study, the design of an epitope B-based vaccine from the HBV polymerase will be carried out. Hepatitis B polymerase sequences were obtained from the NCBI database site and then tested for antigenicity with the Vaxijen server. The results of the hepatitis B protein sequence antigenity test have a protective antigen value of 0.5783 so it is possible to use it as a vaccine candidate.

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References

S. Yu, W. Gao, P. Zeng, C. Chen, Z. Zhang, and Z. Liu, “Biomedicine & Pharmacotherapy Exploring the effect of Gupi Xiaoji Prescription on hepatitis B virus-related liver cancer through network pharmacology and in vitro experiments,” Biomed. Pharmacother., vol. 139, no. December 2020, p. 111612, 2021.

R. S. Rosadha, “POTENSI SENYAWA BIOAKTIF β-CAROTENE SEBAGAI KANDIDAT ANTIVIRUS HEPATITIS B,” J. Geuthèë Penelit. Multidisiplin, vol. 03, no. 01, pp. 393–399, 2020.

D. Chaudhuri, J. Datta, S. Majumder, and K. Giri, “Infection , Genetics and Evolution In silico designing of peptide based vaccine for Hepatitis viruses using reverse vaccinology approach,” Infect. Genet. Evol., vol. 84, no. May, p. 104388, 2020.

A. La Kilo, L. O. Aman, I. Sabihi, and J. La Kilo, “STUDI POTENSI PIRAZOLIN TERSUBSTITUSI 1-N DARI TIOSEMIKARBAZON SEBAGAI AGEN ANTIAMUBA MELALUI UJI IN SILICO,” Indones. J. Chem. Res., vol. 7file:///E, pp. 9–16, 2019.

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Published

2021-12-15

How to Cite

[1]
E. P. Toepak and Rey Kamala Dewi, “Perancangan Vaksin Berbasis Epitop Sel B Untuk Penyakit Hepatitis B: B CELL EPITOP BASED VACCINE DESIGN FOR HEPATITIS B DISEASE”, JJMS, vol. 3, no. 2, pp. 21–23, Dec. 2021.

Issue

Vol. 3 No. 2 (2021): Vol. 3 No. 2 (2021): Edisi Desember 2021

Section

Articles

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Copyright (c) 2023 Jurnal Jejaring Matematika dan Sains

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