Prosiding Kedokteran dan Kesehatan

Analisis Perubahan Kadar Kortisol Serum Setelah Event Bersepeda 30 km Pada Komunitas Pesepeda di Makassar

Donna Kahanjak — 2025-05-13

. Blood glucose is the main source of energy during exercise, especially in endurance sports such as cycling, therefore, in this study, serum cortisol levels will be measured before and after being given treatment in the form of 30 km cycling training. The purpose of this study was to determine changes in serum cortisol levels after a 30 km cycling event in the cycling community in Makassar. The research method was quasi-experimental with a one group pre-test post-test design. Sample selection using the purposive sampling method by meeting the inclusion criteria in the form of active cyclists, cycling for more than one year, men aged 30-60 years, willing to have blood samples taken. Exclusive criteria include having a history of cardiovascular disease and a history of hypertension. A total of 30 respondents were collected at one time for an initial health check and blood sampling (pretest). A week later, a 30 km event was carried out. After the event was completed, the respondents were re-examined for vital signs and blood was taken later (posttest). The collected blood was centrifuged to obtain serum. Then the serum was examined using the ELISA method using a cortisol kit. The results showed a significant decrease in serum cortisol levels of -1.93 µg/dL from 13.33 µg/dL to 11.34 µg/dL (-14.19%) after traveling 30 km. In conclusion, there is a difference between pretest and posttest cortisol levels, so it is concluded that cycling 30 km can reduce cortisol levels in cyclists

Enhancing Lipid-Lowering Effects with DMN-Fucoidan: A New Approach to Hyperlipidemia Treatment

Francisca Diana Alexandra — 2025-05-22

Background: Hyperlipidemia is a common condition associated with increased cardiovascular risk, and novel therapies are needed to effectively manage lipid levels. This study investigates the efficacy of fucoidan-loaded dissolving microneedles (DMNs) as a transdermal therapy for hyperlipidemia in Wistar rats induced by a high-fat diet.

Methods: Wistar rats were divided into four groups and treated for 14 days with normal, DMN-fucoidan, placebo microneedles, and simvastatin. Lipid profiles, including total cholesterol, low-density lipoprotein (LDL), triglycerides, and high-density lipoprotein (HDL), were measured to evaluate treatment effects.

Results: The DMN-fucoidan group showed a significant reduction in total cholesterol (p = 0.005) and LDL (p = 0.012) levels compared to the control and placebo groups. However, no significant changes were observed in triglyceride (p = 0.883) and HDL (p = 0.217) levels. These results suggest that DMN-fucoidan is effective in lowering total cholesterol and LDL levels, but further optimization is needed to address its effects on other lipid parameters.

Conclusion: DMN-fucoidan demonstrates potential as an alternative lipid-lowering therapy, offering advantages in bioavailability and fewer side effects than conventional oral treatments. Further studies are needed to optimize treatment protocols, investigate combination therapies, and assess the long-term efficacy of DMN-based drug delivery systems for hyperlipidemia management.

Keywords: Fucoidan, microneedles, hyperlipidemia, lipid profiles, transdermal therapy.

Tinjauan Literatur: Faktor Risiko Pneumonia pada Balita di Kalimantan Tahun 2025

Thyrister Nina Asarya Sembiring — 2025-05-14

Pneumonia is the most significant cause of morbiditas and mortalitas in balita worldwide and in Indonesia 2023 the coverage of pneumonia in toddlers was 36.95% while in Central Kalimantan (15.6%) with the coverage of pneumonia cases found and treated in 2022 was 12.7%. The purpose of this study was to determine the risk factors for pneumonia in toddlers in Kalimantan. This study uses a literature review approach by utilizing several regional study references in Kalimantan with publication years 2020-2025. The results of the study show that there are several intrinsic factors (age under two years, incomplete immunization status, malnutrition, and lack of exclusive breastfeeding) and extrinsic factors (exposure to passive smoking, use of mosquito repellent with fuel in the home, poor ventilation, air pollution due to forest fires, and socioeconomic status) which profoundly contribute to the incidence of pneumonia. Prevention of pneumonia in toddlers in Kalimantan requires multidimensional efforts through increasing immunization coverage, breast milk feeding promotion, enhancing living conditions, and air pollution control.

Exploring Portulaca oleracea: Potential Therapeutic Role in Acute Mountain Sickness

Muhammad Rifqi Musyaffa — 2025-05-18

Mountain hiking has become a popular global activity, but it poses risks such as Acute Mountain Sickness (AMS), characterized by symptoms like headaches, nausea, and fatigue. Hypoxia-induced oxidative stress and inflammation are key contributors to AMS. While conventional treatments like acetazolamide are widely used, natural remedies such as Portulaca oleracea (purslane or krokot) offer promising alternatives due to their accessibility and therapeutic potential. This study investigates the pharmacological properties of Portulaca oleracea and its potential role in preventing or mitigating AMS symptoms. A narrative review was conducted using PubMed, ScienceDirect, and Google Scholar. Keywords such as "Portulaca oleracea," "bioactive compounds," and "Acute Mountain Sickness" were applied. Studies focusing on antioxidant, anti-inflammatory, antihypoxic, and anti-angiogenic effects relevant to AMS were included. P. oleracea contains bioactive compounds like flavonoids, alkaloids, and organic acids, demonstrating antioxidant, anti-inflammatory, and antihypoxic properties. Ethanol extracts (EEPO) showed neuroprotective effects, modulating erythropoietin expression and maintaining ATP levels under hypoxic conditions. While no human trials directly link P. oleracea to AMS, its pharmacological effects align with AMS pathophysiology, particularly in reducing oxidative stress and inflammation. P. oleracea is a promising natural remedy for AMS, with significant implications for medical and wellness tourism. Future research, including in silico studies (e.g., molecular docking, network pharmacology) and clinical trials, is essential to fully understand its therapeutic potential. These findings highlight its value as an accessible, sustainable solution in altitude medicine and health tourism

Efektivitas In-vivo Gel Peel-Off Mask Berbasis Centella asiatica terhadap Peningkatan Kelembaban Kulit

Nur Khairi — 2025-05-20

Gel peel-off mask merupakan salah satu bentuk sediaan kosmetik yang semakin populer karena kemampuannya memberikan manfaat ganda, seperti membersihkan permukaan kulit sekaligus memberikan hidrasi. Penelitian ini bertujuan untuk merumuskan, mengevaluasi stabilitas, dan mengkaji efektivitas in vivo dari gel peel-off mask berbahan dasar ekstrak daun pegagan (Centella asiatica) sebagai alternatif pelembap kulit berbahan alami. Studi ini menggunakan metode eksperimental laboratorium dengan empat formula berbeda yang divariasikan berdasarkan konsentrasi Polyvinyl Alcohol (PVA), serta dilakukan uji stabilitas fisik dan uji efektivitas terhadap peningkatan kelembaban kulit selama satu minggu. Hasil menunjukkan bahwa formula dengan PVA 13% dan ekstrak pegagan 5% memiliki karakteristik fisik paling stabil, meliputi pH, viskositas, homogenitas, daya lekat, kecepatan pengeringan, serta memberikan peningkatan kelembaban kulit yang signifikan. Kandungan metabolit sekunder seperti asiaticoside, madecassoside, saponin, dan flavonoid diduga berperan dalam mempertahankan hidrasi kulit melalui mekanisme peningkatan barrier kulit dan stimulasi sintesis kolagen. Formulasi ini juga menunjukkan kesesuaian optimal dengan parameter kenyamanan pengguna. Penelitian ini memberikan kontribusi nyata terhadap pengembangan kosmetik herbal modern dan merekomendasikan studi lanjutan berupa uji klinis jangka panjang pada populasi lebih luas guna validasi lebih lanjut.

Peran dan Identifikasi Spesies Lalat Dewasa di Bidang Entomologi Forensik

Indria Augustina — 2025-05-21

Pada kasus kematian penentuan penyebab dan lama waktu kematian pada korban yang dikenal istilah Post Moterm Interval (PMI). Lama waktu kematian ditentukan dengan mengidentifikasi perubahan yang terjadi pada mayat. Pembusukan mempunyai peran dalam menentukan kecepatan mayat dapat membusuk. Entomologi Forensik dapat digunakan pada pemeriksaan mayat yang telah membusuk bila terdapat organisme yang berkembang biak pada mayat tersebut. Lalat merupakan salah satu serangga yang tertarik pada bau busuk mayat dan menggunakan mayat yang membusuk sebagai media perkembangbiakan. Hal ini didukung dari spesies lalat yang menghinggapi, iklim dan temperatur cuaca daerah penemuan mayat tersebut, serta paparan udara pada mayat. Peneliti tertarik melakukan penelitian di bidang entomologi forensik berdasarkan morfologi spesies lalat dewasa yang ditemukan saat pembusukan menggunakan media daging ayam. Hasil penelitian selama 14 hari pada tiga kelompok perlakuan didapatkan lalat Sarchopaga spp. dan Musca spp.

Hubungan Tingkat Pengetahuan Ibu Tentang Perilaku Hidup Bersih dan Sehat Dengan Kejadian Stunting

Aulia Ramadhani Ansar — 2025-05-24

Stunting can be defined as the impaired growth and development in children which is caused by chronic nutritional problems in the long term so that their height is shorter than the standard age. The stunting rate in Palangka Raya City is quite high, namely 27.4% (the Study of the Indonesian Nutritional Status in 2021). One of the factor influencing stunting is the level of knowledge of mothers about clean and healthy living behaviors. Behavior refers to the way a person takes an action. The clean and healthy living behavior (PHBS) that is applied properly by the mother will also provide good benefits to the children. A total of 40% of households in this city implement clean and healthy living behavior (Palangka Raya City Health Profile in 2022), while the Ministry of Health of the Republic of Indonesia in 2019 set the target of 80%. This study aims to determine the relationship between the level of mother's knowledge about clean and healthy living behavior and the occurence of stunting in children under five in the working area of UPT Puskesmas Pahandut, Palangka Raya City. This study used analytic observational method with a crosssectional design. The determination of the sample used a simple random sampling technique with a total of 61 samples. Data were analyzed using bivariate analysis with the Chi Square test. The results of the study showed that 45 mothers had a low level of knowledge in which 34 children experienced stunting, while the other 11 children did not. A total of 16 mothers had a good level of knowledge in which 7 toddlers experienced stunting and 9 children did not. The results of the statistical test showed that there was a significant relationship between the level of knowledge of mothers about the clean and healthy living behavior and the occurence of stunting with a p-value of = 0.002. It can be concluded that there is a significant relationship between the level of mother's knowledge and the occurence of stunting in the working area of the UPT Puskesmas Pahandut, Palangka Raya City

Hubungan Perilaku Penggunaan Air Bersih Dan Cuci Tangan Pakai Sabun Dengan Diare

Parameswara Bentang Cakrawala — 2025-07-17

Diarrhea has a high morbidity and mortality rate on a continent with many developing countries such as Africa and Asia with a prevalence of 1.6 million people. The number of diarrhea cases in Palangka Raya City reached 3,676 cases with a contribution of 2,612 cases from the Pahandut District. Diarrhea was one of the top 10 diseases with the highest prevalence in Palangka Raya City. The purpose of this study is to analyze the relationship between the behavior of using clean water and handwashing with soap with the incidence of diarrhea in the community in Pahandut District. This type of research uses an observational cross-sectional analytic study. The population selected in this study uses a purposive sampling. The sample was taken using a questionnaire totaling 92 people with an age range of 19-70 years. The results of statistical analysis from 92 respondents (19 to 70 years old) showed that 33 people (35.9%) had diarrhea in the last three months, 56 people (60.8%) had good clean water usage behavior, and 60 people (65.2%) had washed their hands with soap. This study concludes that there is a relationship between the behavior of using clean water with the incidence of diarrhea with a value of p = 0.000 and there is a relationship between handwashing with soap and the incidence of diarrhea with a value of p = 0.006.

Hubungan antara Kepatuhan Penggunaan Obat Pasien Diabetes Mellitus Tipe 2 dengan Komplikasi Penyakit Jantung Korener

Fidela Amadea Dyna Setyaji — 2025-07-17

Diabetes mellitus (DM) is a well-established risk factor for coronary heart disease (CHD), making it a major public health problem worldwide. DM patients are two to four times more likely to develop CHD. Previous studies have shown that uncontrolled blood sugar levels may increase the risk of CHD. Therefore, adherence to medication is essential for patients with chronic diseases such as type 2 diabetes (T2DM). The aim of this study was to assess the association between medication adherence and complications of coronary heart disease. This was a retrospective case-control study using a dataset provided by Dr. Doris Silvanus Hospital in Palangka Raya. The sample was divided into two groups; one had CHD as a complication, while the other had no CHD complication. Sixty-three subjects were eligible for this study (21 with CHD complications and 42 with non-CHD complications). Statistical analysis showed that adherence to antidiabetic drugs had a significant (P-value < 0.001) and moderate (r = 0.538) correlation with CHD complications. In this study, adherence to diabetes medications was found to be significantly correlated with complications of coronary heart disease.

Pneumonia pada Anak disertai Kejang Demam Kompleks

Adelgrit Trisia — 2025-07-17

Pneumonia in early childhood can present with systemic manifestations such as complex febrile seizures. We report the case of a 2-year-5-month-old girl who experienced two generalized seizures within 24 hours accompanied by fever, without prominent respiratory complaints at onset. Physical examination revealed tachypnea and bilateral rhonchi, while chest radiography showed infiltrates and apical consolidation. Laboratory results showed leukocytosis and monocytosis. The patient was diagnosed with community-acquired pneumonia triggering complex febrile seizures. Management included antipyretics, phenobarbital, and intravenous ampicillin-sulbactam. Pneumonia was diagnosed as the trigger of complex febrile seizures, and the patient showed a good clinical response to supportive and antibiotic therapy