Enhancing Lipid-Lowering Effects with DMN-Fucoidan: A New Approach to Hyperlipidemia Treatment
Keywords:
Fucoidan, Microneedles, Hyperlipidemia, Lipid profiles, Transdermal therapyAbstract
Background: Hyperlipidemia is a common condition associated with increased cardiovascular risk, and novel therapies are needed to effectively manage lipid levels. This study investigates the efficacy of fucoidan-loaded dissolving microneedles (DMNs) as a transdermal therapy for hyperlipidemia in Wistar rats induced by a high-fat diet.
Methods: Wistar rats were divided into four groups and treated for 14 days with normal, DMN-fucoidan, placebo microneedles, and simvastatin. Lipid profiles, including total cholesterol, low-density lipoprotein (LDL), triglycerides, and high-density lipoprotein (HDL), were measured to evaluate treatment effects.
Results: The DMN-fucoidan group showed a significant reduction in total cholesterol (p = 0.005) and LDL (p = 0.012) levels compared to the control and placebo groups. However, no significant changes were observed in triglyceride (p = 0.883) and HDL (p = 0.217) levels. These results suggest that DMN-fucoidan is effective in lowering total cholesterol and LDL levels, but further optimization is needed to address its effects on other lipid parameters.
Conclusion: DMN-fucoidan demonstrates potential as an alternative lipid-lowering therapy, offering advantages in bioavailability and fewer side effects than conventional oral treatments. Further studies are needed to optimize treatment protocols, investigate combination therapies, and assess the long-term efficacy of DMN-based drug delivery systems for hyperlipidemia management.
Keywords: Fucoidan, microneedles, hyperlipidemia, lipid profiles, transdermal therapy.
References
Liu H, Xu S, Li G, Lou D, Fu X, Lu Q, et al. Sarpogrelate and Rosuvastatin Synergistically Ameliorate Aortic Damage Induced by Hyperlipidemia in Apolipoprotein E‑deficient Mice. Exp Ther Med 2020;20(6):1.
Wang H, Fu Y, Liu P, Qu F, Du S, Li Y, et al. Supramolecular Dissolving Microneedle Patch Loading Hydrophobic Glucocorticoid for Effective Psoriasis Treatment. ACS Appl Mater Interfaces 2023;15(12):15162–71.
Zhang Y, Liu T, Qu Z, Wang X, Song WG, Guo S. Laminaria Japonica Aresch‐Derived Fucoidan Ameliorates Hyperlipidemia by Upregulating LXRs and Suppressing SREBPs. Cardiovasc Ther 2024;2024(1).
Yang Z, Liu G, Wang Y, Yin J, Jin W, Xia B, et al. Fucoidan A2 From the Brown Seaweed Ascophyllum Nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57bl/6j Mice Fed a High-Fat Diet. J Agric Food Chem 2019;67(20):5782–91.
Ahmad T, Eapen MS, Ishaq M, Park AY, Karpiniec SS, Stringer DN, et al. Anti-Inflammatory Activity of Fucoidan Extracts in Vitro. Mar Drugs 2021;19(12):702.
Lukova P, Apostolova E, Baldzhieva A, Murdjeva M, Kokova V. Fucoidan From Ericaria Crinita Alleviates Inflammation in Rat Paw Edema, Downregulates Pro-Inflammatory Cytokine Levels, and Shows Antioxidant Activity. Biomedicines 2023;11(9):2511.
Pozharitskaya ON, Shikov AN, Shikov AN, Obluchinskaya ED, Vuorela H. The Pharmacokinetics of Fucoidan after Topical Application to Rats. Mar Drugs [Internet] 2019;Available from: https://pubmed.ncbi.nlm.nih.gov/31817687
He Y, Li Y, Shen P, Li S, Zhang L, Wang Q, et al. Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared From Iceland Brown Algae Ascophyllum Nodosum in an Hyperlipidemic Mice Model. Mar Drugs 2023;21(9):468.
Shin D, Shim SR, Wu Y, Hong G, Jeon H, Kim C, et al. How Do Brown Seaweeds Work on Biomarkers of Dyslipidemia? A Systematic Review With Meta-Analysis and Meta-Regression. Mar Drugs 2023;21(4):220.
Nirwan N, Vohora D. Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulating BMP-2 and Sclerostin in the High-Fat Diet Fed C57bl/6 Mice. Front Endocrinol (Lausanne) 2022;13.
Luo M, Fan R, Wang X, Lu J, Li P, Chu W, et al. Gualou Xiebai Banxia Decoction Ameliorates Poloxamer 407-Induced Hyperlipidemia. Biosci Rep 2021;41(6).
Cao K, Lv W, Liu X, Fan Y, Wang K, Feng Z, et al. Herba Houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade. Nutrients 2020;12(1):164.
Tan W, Li X, Zheng S, Li X, Zhang X, Pyle WG, et al. A Porcine Model of Heart Failure With Preserved Ejection Fraction Induced by Chronic Pressure Overload Characterized by Cardiac Fibrosis and Remodeling. Front Cardiovasc Med 2021;8.
Chen J, Hui R, Zhou P, Zheng S, Du B, Liu X, et al. Microneedle-Mediated Drug Delivery for Cutaneous Diseases. Front Bioeng Biotechnol 2022;10.
Wang J, Hwang S, Lim D, Son C. Cynanchum Atratum Alleviates Non-Alcoholic Fatty Liver by Balancing Lipogenesis and Fatty Acid Oxidation in a High-Fat, High-Fructose Diet Mice Model. Cells 2021;11(1):23.
Stephanie S, Enggi CK, Sulistiawati S, Tangdilintin F, Achmad AA, Litaay M, et al. Fucoidan-incorporated dissolving microneedles: A novel approach to anticoagulant transdermal delivery. J Drug Deliv Sci Technol [Internet] 2024;95:105587. Available from: https://doi.org/10.1016/j.jddst.2024.105587
Zech J, Dzikowski R, Simantov K, Golenser J, Mäder K. Transdermal Delivery of Artemisinins for Treatment of Pre-Clinical Cerebral Malaria. Int J Parasitol Drugs Drug Resist 2021;16:148–54.
Alimardani V, Abolmaali SS, Yousefi G, Rahiminezhad Z, Abedi M, Tamaddon AM, et al. Microneedle Arrays Combined With Nanomedicine Approaches for Transdermal Delivery of Therapeutics. J Clin Med 2021;10(2):181.
Mishra P, - KM, - MPD. Formulation and Characterization of Griseofulvin Liposome Loaded Topical Film. Int J Multidiscip Res 2023;5(5).
Permana AD, Paredes AJ, Volpe-Zanutto F, Anjani QK, Utomo E, Donnelly RF. Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis. Eur J Pharm Biopharm [Internet] 2020;154(June):50–61. Available from: https://doi.org/10.1016/j.ejpb.2020.06.025
Xu F, Shen L, Yang Y, Kong L, Zu W, Tian D, et al. Association Between Plasma Levels of ANGPTL3, 4, 8 and the Most Common Additional Cardiovascular Risk Factors in Patients With Hypertension. Diabetes Metab Syndr Obes Targets Ther 2023;Volume 16:1647–55.
Din NAS, Ishak AA, Maarof S, Rahman HA, Sofian‐Seng N, Razali NSM, et al. Potential Anti‐obesity Effects of Fucoidan From Malaysian Brown Seaweed (Sargassum Binderi) by in Vivo Study. Int J Food Sci Technol 2024;59(5):3402–11.
Lin P, Chen S, Zhong S. Nutritional and Chemical Composition of Sargassum Zhangii and the Physical and Chemical Characterization, Binding Bile Acid, and Cholesterol-Lowering Activity in HepG2 Cells of Its Fucoidans. Foods 2022;11(12):1771.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Prosiding Kedokteran dan Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
