Exploring Portulaca oleracea: Potential Therapeutic Role in Acute Mountain Sickness
Keywords:
Exploration, Portulaca oleracea, Acute Mountain SicknessAbstract
Mountain hiking has become a popular global activity, but it poses risks such as Acute Mountain Sickness (AMS), characterized by symptoms like headaches, nausea, and fatigue. Hypoxia-induced oxidative stress and inflammation are key contributors to AMS. While conventional treatments like acetazolamide are widely used, natural remedies such as Portulaca oleracea (purslane or krokot) offer promising alternatives due to their accessibility and therapeutic potential. This study investigates the pharmacological properties of Portulaca oleracea and its potential role in preventing or mitigating AMS symptoms. A narrative review was conducted using PubMed, ScienceDirect, and Google Scholar. Keywords such as "Portulaca oleracea," "bioactive compounds," and "Acute Mountain Sickness" were applied. Studies focusing on antioxidant, anti-inflammatory, antihypoxic, and anti-angiogenic effects relevant to AMS were included. P. oleracea contains bioactive compounds like flavonoids, alkaloids, and organic acids, demonstrating antioxidant, anti-inflammatory, and antihypoxic properties. Ethanol extracts (EEPO) showed neuroprotective effects, modulating erythropoietin expression and maintaining ATP levels under hypoxic conditions. While no human trials directly link P. oleracea to AMS, its pharmacological effects align with AMS pathophysiology, particularly in reducing oxidative stress and inflammation. P. oleracea is a promising natural remedy for AMS, with significant implications for medical and wellness tourism. Future research, including in silico studies (e.g., molecular docking, network pharmacology) and clinical trials, is essential to fully understand its therapeutic potential. These findings highlight its value as an accessible, sustainable solution in altitude medicine and health tourism
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