Uji aktivitas antihiperglikemia ekstrak batang Uncaria gambir (W.Hunter) Roxb. pada tikus diabetes
DOI:
https://doi.org/10.37304/jkupr.v11i1.8577Keywords:
antihyperglycemic, blood glucose, diabetes, Uncaria gambir (W.Hunter) RoxbAbstract
This study aimed to prove the antihyperglycemic activity of the ethanol extract of bajakah Tampala stem (Uncaria gambir (W.Hunter) Roxb.) in rats induced by streptozotocin. The research was conducted experimentally using a true experiment posttest-only control group design. bajakah Tampala extract was extracted by maceration method using 96% ethanol solvent. The extract was made at 50mg/kgBB, 75mg/KgBB, and 100mg/KgBB in diabetic rats. The decrease in blood glucose levels of the negative control (27.27%) in this treatment was lower than that of glibenclamide (35.12%). The most significant decrease in blood glucose levels was achieved by 100 mg/kg BW, which was 44.85%. The treatment of Bajakah ethanol extract at various dose levels at the end of the observation showed a decrease in blood glucose levels but was not significantly different (p > 0.05). The results of this study did not show a significantly different decrease in blood glucose levels.
Downloads
References
Soelistijo S. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. Glob Initiat Asthma. Published online 2021:46. www.ginasthma.org.
International Diabetes Federation. IDF Diabetes Atlas, 9th Edn. Brussels, Belgium.; 2019. http://www.idf.org/sites/default/files/Atlas-poster-2014_ES.pdf
Kemenkes RI. Hasil Riset Kesehatan Dasar Tahun 2018. Kementrian Kesehat RI. 2018;53(9):1689-1699.
Lee PG, Halter JB. The pathophysiology of hyperglycemia in older adults: Clinical considerations. Diabetes Care. 2017;40(4):444-452. doi:10.2337/dc16-1732
Hasanah F. SKRINING FITOKIMIA DAN FORMULASI SEDIAAN MASKER PEEL-OFF EKSTRAK ETANOL GAMBIR (Uncaria gambir (W. HUNTER) ROXB) SECARA PERKOLASI. BIOLINK (Jurnal Biol Lingkung Ind Kesehatan). 2019;5(2):114-122. doi:10.31289/biolink.v5i2.1757
Mat Saad MF, Goh HH, Rajikan R, Tuan Yusof TR, Baharum SN, Bunawan H. From phytochemical composition to pharmacological importance. Trop J Pharm Res. 2020;19(8):1767-1773. doi:10.4314/tjpr.v19i8.28
Hartanti L, Ashari AM, Warsidah W. Total Phenol and Antioxidant Activity of Ethanol Extract and Water Extract from Claw Uncariaa gambir Roxb. Berk Sainstek. 2021;9(3):131. doi:10.19184/bst.v9i3.27179
Arundita S, Kurniawan F, Ismed F, Rita RS, Putra DP. In vitro alpha glucosidase activity of uncaria gambir roxb. And syzygium polyanthum (wight) walp. From West Sumatra, Indonesia. Open Access Maced J Med Sci. 2020;8(A):810-817. doi:10.3889/oamjms.2020.4298
Handayani TW, Yusuf Y, Tandi J. Analisis Kualitatif dan Kuantitatif Metabolit Sekunder Ekstrak Biji Kelor ( Moringa oleifera Lam . ) dengan Metode Spektrofotometri UV- Vis. KOVALEN J Ris Kim. 2020;6(3):230-238. doi:https://doi.org/10.22487/kovalen.2020.v6.i3.15324
Noviyanty A, Salingkat CA, Syamsiar S. PENGARUH JENIS PELARUT TERHADAP EKSTRAKSI DARI KULIT BUAH NAGA MERAH (Hylocereus polyrhizus). KOVALEN J Ris Kim. 2019;5(3):271-279. doi:10.22487/kovalen.2019.v5.i3.14037
Liwu AN, Lidia K, Amat ALS. Pengaruh Ekstrak Etanol Daun Afrika Selatan (Vernonia amygdalina Delile) Terhadap Kadar Glukosa Darah Tikus Putih (Rattus norvegicus) Yang Dinduksi Aloksan. Cendana Med J. 2019;7(2):299-307. doi:https://doi.org/10.35508/cmj.v7i2.1803
Indrawati S, Yuliet Y, Ihwan I. Indrawati S, Yuliet Y, Ihwan I. Efek Antidiabetes Ekstrak Air Kulit Buah Pisang Ambon (Musa paradisiaca L.) Terhadap Mencit (Mus musculus) Model Hiperglikemia. J Farm Galen (Galenika J Pharmacy). 2015;1(2):133-140. doi:10.22487/j24428744.2015.v1.i2.6245
Sun C, Zhao C, Guven EC, et al. Dietary polyphenols as antidiabetic agents: Advances and opportunities. Food Front. 2020;1(1):18-44. doi:10.1002/fft2.15
Putta S, Sastry Yarla N, Kumar Kilari E, et al. Therapeutic Potentials of Triterpenes in Diabetes and its Associated Complications. Curr Top Med Chem. 2016;16(23):2532-2542. doi:10.2174/1568026616666160414123343
Saputra NT, Suartha IN, Dharmayudha AAGO. Agen Diabetagonik Streptozotocin untuk Membuat Tikus Putih Jantan Diabetes Mellitus. Bul Vet Udayana. 2018;10(2):116. doi:10.24843/bulvet.2018.v10.i02.p02
Radenković M, Stojanović M, Prostran M. Experimental diabetes induced by alloxan and streptozotocin: The current state of the art. J Pharmacol Toxicol Methods. 2016;78:13-31. doi:10.1016/j.vascn.2015.11.004
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Jurnal Kedokteran Universitas Palangka Raya
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
