Profil manifestasi klinis dan laboratorium pasien demam tifoid di Rumah Sakit PKU Bantul


  • Ninda Devita Department Mikrobiologi, Fakultas Kedokteran, Universitas Islam Indonesia
  • Muhammad Syafiq Riski RSUD Wonosari, Yogyakarta
  • Rian Marufi Program Studi Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada
  • Ulil Albab Habibah Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Islam Indonesia, Yogyakarta



typhoid fever, clinical manifestation, laboratory test


Typhoid fever can give various clinical manifestations and laboratoryThis study is a retrospective descriptive study using medical record data. The data collected was clinical manifestations and laboratory then presented in a frequency distribution diagram. A total of 72 typhoid fever patients at PKU Hospital Bantul in 2014-2015 were included as subjects. A 53% of the subjects were women. The mean age was 32 ± 14 years. The main symptoms were fever (99%), gastrointestinal symptoms (91%), headache (37%), muscle aches (11%), and cough (8%). The dominant physical examination found hepatomegaly and dirty tongue (19% and 5%). The main laboratory abnormalities were increased SGOT (46%), SGPT (39%), anemia (26%), and leukopenia (22%) It was concluded, typhoid fever patients often found fever, gastrointestinal symptoms, headache accompanied by anemia, leukopenia, and elevated liver enzymes in laboratory tests.





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Manesh, A. et al. Typhoid and paratyphoid fever: A clinical seminar. J Travel Med 28, 1–13 (2021). doi: 10.1093/jtm/taab012.

Stanaway, J. D. et al. The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect Dis 19, 369–381 (2019). doi: 10.1016/S1473-3099(18)30685-6.

Ajibola, O., Mshelia, M. B., Gulumbe, B. H. & Eze, A. A. Typhoid fever diagnosis in endemic countries: A clog in the wheel of progress? Medicina (Lithuania) 54, 1–12 (2018). doi: 10.3390/medicina54020023.

Hancuh, M. et al. Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction — Worldwide, 2018–2022. MMWR Morb Mortal Wkly Rep 72, 171–176 (2023). doi: 10.15585/mmwr.mm7207a2.

Habte, L., Tadesse, E., Ferede, G. & Amsalu, A. Typhoid fever: Clinical presentation and associated factors in febrile patients visiting Shashemene Referral Hospital, southern Ethiopia. BMC Res Notes 11, 1–6 (2018). doi: 10.1186/s13104-018-3713-y.

Bhutta, Z. A. Current concepts in the diagnosis and treatment of typhoid fever. Br Med J 333, 78–82 (2006). doi: 10.1136/bmj.333.7558.78.

Aneley Getahun, S. et al. A retrospective study of patients with blood culture-confirmed typhoid fever in Fiji during 2014-2015: Epidemiology, clinical features, treatment and outcome. Trans R Soc Trop Med Hyg 113, 764–770 (2019). doi: 10.1093/trstmh/trz075.

Iqbal, N. et al. Clinicopathological profile of Salmonella Typhi and Paratyphi infections presenting as fever of unknown origin in a

tropical country. Mediterr J Hematol Infect Dis 7, (2015). doi: 10.4084/MJHID.2015.021.

Pohan, H. T. Clinical and laboratory manifestations of typhoid fever at Persahabatan Hospital, Jakarta. Acta Med Indones 36, 78–83 (2004). PMID: 15673941.

Britto, C. D. et al. Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes. Trop Med Health 48, (2020). doi: 10.1186/s41182-020-00247-2.

Sarma, A. & Barkataki, D. Comparative Study Of Blood Culture with Rapid Diagnostic Tests for Diagnosis Of Enteric Fever In A Tertiary Centre Of NE-India. Jms Skims 22, 21–26 (2019).

Sultana, S., Maruf, A. Al, Sultana, R. & Jahan, S. Laboratory Diagnosis of Enteric Fever : A Review Update. Bangladesh Journal of Infectious Diseases. 3, 43–51 (2016). DOI:10.3329/bjid.v3i2.33834.

Aiemjoy, K. et al. Diagnostic Value of Clinical Features to Distinguish Enteric Fever from Other Febrile Illnesses in Bangladesh, Nepal, and Pakistan. Clinical Infectious Diseases 71, S257–S265 (2020). doi: 10.1093/cid/ciaa1297.

PB IDI. Panduan Praktik Klinis Bagi Dokter di Fasilitas Pelayanan Kesehatan Primer. (2013). ISBN 9786024160647

WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva, Switzerland: World Health Organization 1–6 (2011) doi:2011.

Naushad, H. Leukocyte Count (WBC): Reference Range, Interpretation, Collection and Panels. Medscape Preprint at (2022).

NIH. Platelet Disorders - Thrombocytopenia | NHLBI, NIH. (2022).

Permata Nasution, D. Gambaran Kadar Enzim Aspartat Aminotransferase (Ast) Dan Enzim Alanin Aminotransferase (Alt) Pada Pasien Penderita Sirosis Hati Di Rumah Sakit Efarina Etaham Berastagi. Jurnal Ilmiah Multidisiplin 1 (5), (2022). ISSN : 2810-0581.

Afifah, N. R. & Pawenang, E. T. Kejadian Demam Tifoid pada Usia 15-44 Tahun. Higea Jornal of Public Health Research and Development 3, 263–273 (2019).

Rasul, F. et al. Surveillance report on typhoid fever epidemiology and risk factor assessment in district Gujrat , Punjab , Pakistan . (2017).

Kanj, S. S. et al. Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon. J Epidemiol Glob Health 5, 159–165 (2015). doi: 10.1016/j.jegh.2014.07.003.

Farmakiotis, D. et al. Typhoid fever in an inner city hospital: A 5-year retrospective review. J Travel Med 20, 17–21 (2013). doi: 10.1111/j.1708-8305.2012.00665.x.

Limpitikul, W., Henpraserttae, N., Saksawad, R. & Laoprasopwattana, K. Typhoid outbreak in Songkhla, Thailand 2009-2011: Clinical outcomes, susceptibility patterns, and reliability of serology tests. PLoS One 9, 7–12 (2014). doi: 10.1371/journal.pone.0111768.

Gal-Mor, O., Boyle, E. C. & Grassl, G. A. Same species, different diseases: How and why typhoidal and non-typhoidal Salmonella enterica serovars differ. Front Microbiol 5, 1–10 (2014). doi: 10.3389/fmicb.2014.00391.

Noor, M., Rahim, F., Amin, S., Ullah, R. & Zafar, S. A Patient With Fever, Loose Motions and Jaundice: Hickam’s Dictum or Occam’s Razor. Cureus 14, (2022). doi: 10.7759/cureus.23295.

Di Domenico, E. G., Cavallo, I., Pontone, M., Toma, L. & Ensoli, F. Biofilm producing Salmonella typhi: Chronic colonization and development of gallbladder cancer. Int J Mol Sci 18, (2017). doi: 10.3390/ijms18091887.

Bhume, R. J. & Babaliche, P. Clinical profile and the role of rapid serological tests: Typhifast igm and enterocheck wb in the diagnosis of typhoid fever. Indian Journal of Critical Care Medicine 24, 307–312 (2020). doi: 10.5005/jp-journals-10071-23417.

Akbayram, S. et al. Clinical and Hematological Manifestations of Typhoid Fever in Children in Eastern Turkey. West Indian Medical Journal 65, 154–157 (2016). doi: 10.7727/wimj.2014.354.

Ndako, J. A. et al. Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria. Heliyon 6, e04002 (2020). doi: 10.1016/j.heliyon.2020.e04002..




How to Cite

Devita, N., Riski, M. S., Marufi, R., & Habibah, U. A. (2023). Profil manifestasi klinis dan laboratorium pasien demam tifoid di Rumah Sakit PKU Bantul. Jurnal Kedokteran Universitas Palangka Raya, 11(2).