Profil manifestasi klinis dan laboratorium pasien demam tifoid di Rumah Sakit PKU Bantul

Authors

  • Ninda Devita Department Mikrobiologi, Fakultas Kedokteran, Universitas Islam Indonesia
  • Muhammad Syafiq Riski RSUD Wonosari, Yogyakarta https://orcid.org/0000-0002-4122-679X
  • Rian Marufi Program Studi Spesialis Ilmu Penyakit Dalam, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada https://orcid.org/0009-0000-3603-6468
  • Ulil Albab Habibah Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Islam Indonesia, Yogyakarta

DOI:

https://doi.org/10.37304/jkupr.v11i2.10753

Keywords:

typhoid fever, clinical manifestation, laboratory test

Abstract

Typhoid fever can give various clinical manifestations and laboratoryThis study is a retrospective descriptive study using medical record data. The data collected was clinical manifestations and laboratory then presented in a frequency distribution diagram. A total of 72 typhoid fever patients at PKU Hospital Bantul in 2014-2015 were included as subjects. A 53% of the subjects were women. The mean age was 32 ± 14 years. The main symptoms were fever (99%), gastrointestinal symptoms (91%), headache (37%), muscle aches (11%), and cough (8%). The dominant physical examination found hepatomegaly and dirty tongue (19% and 5%). The main laboratory abnormalities were increased SGOT (46%), SGPT (39%), anemia (26%), and leukopenia (22%) It was concluded, typhoid fever patients often found fever, gastrointestinal symptoms, headache accompanied by anemia, leukopenia, and elevated liver enzymes in laboratory tests.

 

 

 

Downloads

Download data is not yet available.

References

Manesh, A. et al. Typhoid and paratyphoid fever: A clinical seminar. J Travel Med 28, 1–13 (2021). doi: 10.1093/jtm/taab012.

Stanaway, J. D. et al. The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect Dis 19, 369–381 (2019). doi: 10.1016/S1473-3099(18)30685-6.

Ajibola, O., Mshelia, M. B., Gulumbe, B. H. & Eze, A. A. Typhoid fever diagnosis in endemic countries: A clog in the wheel of progress? Medicina (Lithuania) 54, 1–12 (2018). doi: 10.3390/medicina54020023.

Hancuh, M. et al. Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction — Worldwide, 2018–2022. MMWR Morb Mortal Wkly Rep 72, 171–176 (2023). doi: 10.15585/mmwr.mm7207a2.

Habte, L., Tadesse, E., Ferede, G. & Amsalu, A. Typhoid fever: Clinical presentation and associated factors in febrile patients visiting Shashemene Referral Hospital, southern Ethiopia. BMC Res Notes 11, 1–6 (2018). doi: 10.1186/s13104-018-3713-y.

Bhutta, Z. A. Current concepts in the diagnosis and treatment of typhoid fever. Br Med J 333, 78–82 (2006). doi: 10.1136/bmj.333.7558.78.

Aneley Getahun, S. et al. A retrospective study of patients with blood culture-confirmed typhoid fever in Fiji during 2014-2015: Epidemiology, clinical features, treatment and outcome. Trans R Soc Trop Med Hyg 113, 764–770 (2019). doi: 10.1093/trstmh/trz075.

Iqbal, N. et al. Clinicopathological profile of Salmonella Typhi and Paratyphi infections presenting as fever of unknown origin in a

tropical country. Mediterr J Hematol Infect Dis 7, (2015). doi: 10.4084/MJHID.2015.021.

Pohan, H. T. Clinical and laboratory manifestations of typhoid fever at Persahabatan Hospital, Jakarta. Acta Med Indones 36, 78–83 (2004). PMID: 15673941.

Britto, C. D. et al. Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes. Trop Med Health 48, (2020). doi: 10.1186/s41182-020-00247-2.

Sarma, A. & Barkataki, D. Comparative Study Of Blood Culture with Rapid Diagnostic Tests for Diagnosis Of Enteric Fever In A Tertiary Centre Of NE-India. Jms Skims 22, 21–26 (2019).https://doi.org/10.33883/jms.v22i3.474

Sultana, S., Maruf, A. Al, Sultana, R. & Jahan, S. Laboratory Diagnosis of Enteric Fever : A Review Update. Bangladesh Journal of Infectious Diseases. 3, 43–51 (2016). DOI:10.3329/bjid.v3i2.33834.

Aiemjoy, K. et al. Diagnostic Value of Clinical Features to Distinguish Enteric Fever from Other Febrile Illnesses in Bangladesh, Nepal, and Pakistan. Clinical Infectious Diseases 71, S257–S265 (2020). doi: 10.1093/cid/ciaa1297.

PB IDI. Panduan Praktik Klinis Bagi Dokter di Fasilitas Pelayanan Kesehatan Primer. (2013). ISBN 9786024160647

WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva, Switzerland: World Health Organization 1–6 (2011) doi:2011.

Naushad, H. Leukocyte Count (WBC): Reference Range, Interpretation, Collection and Panels. Medscape Preprint at https://emedicine.medscape.com/article/2054452-overview?reg=1 (2022).

NIH. Platelet Disorders - Thrombocytopenia | NHLBI, NIH. https://www.nhlbi.nih.gov/health/thrombocytopenia (2022).

Permata Nasution, D. Gambaran Kadar Enzim Aspartat Aminotransferase (Ast) Dan Enzim Alanin Aminotransferase (Alt) Pada Pasien Penderita Sirosis Hati Di Rumah Sakit Efarina Etaham Berastagi. Jurnal Ilmiah Multidisiplin 1 (5), (2022). ISSN : 2810-0581.

Afifah, N. R. & Pawenang, E. T. Kejadian Demam Tifoid pada Usia 15-44 Tahun. Higea Jornal of Public Health Research and Development 3, 263–273 (2019). https://doi.org/10.15294/higeia.v3i2.24387

Rasul, F. et al. Surveillance report on typhoid fever epidemiology and risk factor assessment in district Gujrat , Punjab , Pakistan . (2017).

Kanj, S. S. et al. Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon. J Epidemiol Glob Health 5, 159–165 (2015). doi: 10.1016/j.jegh.2014.07.003.

Farmakiotis, D. et al. Typhoid fever in an inner city hospital: A 5-year retrospective review. J Travel Med 20, 17–21 (2013). doi: 10.1111/j.1708-8305.2012.00665.x.

Limpitikul, W., Henpraserttae, N., Saksawad, R. & Laoprasopwattana, K. Typhoid outbreak in Songkhla, Thailand 2009-2011: Clinical outcomes, susceptibility patterns, and reliability of serology tests. PLoS One 9, 7–12 (2014). doi: 10.1371/journal.pone.0111768.

Gal-Mor, O., Boyle, E. C. & Grassl, G. A. Same species, different diseases: How and why typhoidal and non-typhoidal Salmonella enterica serovars differ. Front Microbiol 5, 1–10 (2014). doi: 10.3389/fmicb.2014.00391.

Noor, M., Rahim, F., Amin, S., Ullah, R. & Zafar, S. A Patient With Fever, Loose Motions and Jaundice: Hickam’s Dictum or Occam’s Razor. Cureus 14, (2022). doi: 10.7759/cureus.23295.

Di Domenico, E. G., Cavallo, I., Pontone, M., Toma, L. & Ensoli, F. Biofilm producing Salmonella typhi: Chronic colonization and development of gallbladder cancer. Int J Mol Sci 18, (2017). doi: 10.3390/ijms18091887.

Bhume, R. J. & Babaliche, P. Clinical profile and the role of rapid serological tests: Typhifast igm and enterocheck wb in the diagnosis of typhoid fever. Indian Journal of Critical Care Medicine 24, 307–312 (2020). doi: 10.5005/jp-journals-10071-23417.

Akbayram, S. et al. Clinical and Hematological Manifestations of Typhoid Fever in Children in Eastern Turkey. West Indian Medical Journal 65, 154–157 (2016). doi: 10.7727/wimj.2014.354.

Ndako, J. A. et al. Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria. Heliyon 6, e04002 (2020). doi: 10.1016/j.heliyon.2020.e04002..

Downloads

Published

2023-10-27

How to Cite

Devita, N., Riski, M. S., Marufi, R., & Habibah, U. A. (2023). Profil manifestasi klinis dan laboratorium pasien demam tifoid di Rumah Sakit PKU Bantul. Jurnal Kedokteran Universitas Palangka Raya, 11(2). https://doi.org/10.37304/jkupr.v11i2.10753