Efektivitas infusa daun kalakai (Stenochlaena palustris (Burm.F) Bedd) terhadap kadar kolesterol total pada tikus putih galur wistar yang diinduksi CCl4
DOI:
https://doi.org/10.37304/barigas.v2i3.12183Kata Kunci:
Kolesterol total, daun kalakai, CCl4, infusaAbstrak
Cholesterol can be attacked by CCl4 by increasing lipid peroxidation, where CCl4 causes an increase in acetate transport into the liver, resulting in an increase in substrate (acetate) which causes cholesterol synthesis to also increase. Based on previous research, the kalakai plant (Stenochlaena palustris (Burm.F) Bedd) has good antioxidants to ward off free radicals. Objective: To determine the potential of kalakai leaf infusion to prevent the increase in total cholesterol levels induced by CCl4. Method: True experimental research with a post test only control group design, using 24 white male Wistar rats weighing 200-250 g, divided into three treatment groups and a negative (-) group induced by CCl4. Treatment groups I, II, II were given kalakai leaf infusion at a dose of 300 mg/kgBW, 400 mg/kgBW, 500 mg/kgBW. This research was conducted for 15 days. Research Results: In the normality and homogeneity test, the sig>0.05 value was obtained, so it can be concluded that the data is normally and homogeneously distributed. Then the data can be continued for Oneway ANOVA hypothesis testing, and a value of sig>0.05 is obtained. Based on the research results, there was no effect from the kalakai leaf infusion and the hypothesis was rejected.
Unduhan
Referensi
Adawiyah R, Sartika F, Arfianto F. Potensi Ekstrak Akar Kalakai (Stenochlaena palutris Bedd) Sebagai Antihiperlipidemia Yang Diuji Secara In Vivo. J Pharmascience. 2020;7(1):62. doi.org/10.20527/jps.v7i1.8075
Jihan, Ramadhan A, Sutrisnawati, Isnainar. Kombinasi Ekstrak Daun Pare (Momordica charantia) dan Kunyit (Curcuma longa) Terhadap Jumlah Sel Darah Merah dan Sel Darah Putih Tikus (Rattus norvegicus) yang Diinduksi CCl 4 dan Pemanfaatannya Sebagai Media Pembelajaran. J Biol Sci Educ [Internet]. 2021;9(1):745–54. Available from: http://jurnal.fkip.untad.ac.id. doi.org/10.22487/jbse.v9i2.1733
Hernasari. Efek Antihiperlipidemia Ekstrak Etanol Daun Alpukat (Persea americana Mill) Pada Tikus Putih Jantan yang Diberi Diet Tinggi Kolesterol dan Lemak. 2010;1–86.
Fahruni F, Handayani R, Novaryatiin S. Potensi Tumbuhan Kelakai (Stenochlaena palustris (Burm.F.) Bedd.) asal Kalimantan Tengah sebagai Afrodisiaka. J Surya Med. 2018;3(2):144–53. doi.org/10.33084/jsm.v3i2.114
Ainia N. Uji Fitokimia Infusa Pekat Buah Pare (Momordica charantia L.) dan Pengaruh Lama Terapi dengan Variasi Dosis Terhadap Penurunan Kadar Glukosa Darah Tikus (Rattus norvegicus) yang Diinduksi Aloksan. skripsi Maulana Malik Ibrahim State Islam Univ Malang. 2017;1–161.
Ikalinus R, Widyastuti S, Eka Setiasih N. Skrining Fitokimia Ekstrak Etanol Kulit Batang Kelor (Moringa Oleifera). Indones Med Veterinus. 2015;4(1):77.
Puspasari AF, Agustini SM, Illahika AP. Pengaruh Ekstrak Daun Kersen (Muntingia Calabra L.) Terhadap Profil Lipid Mencit Putih (Mus Musculus) Jantan Yang Diinduksi Minyak Jelantah. Saintika Med. 2016;12(1):49. doi.org/10.22219/sm.v12i1.5260
Wahid AR, Safwan S. Skrining Fitokimia Senyawa Metabolit Sekunder Terhadap Ekstrak Tanaman Ranting Patah Tulang (Euphorbia tirucalli L.). Lumbung Farm J Ilmu Kefarmasian. 2020;1(1):24. doi.org/10.31764/lf.v1i1.1208
Novriyanti R, Putri NEK, Rijai L. Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Jeruk Nipis (Citrus aurantifolia) Menggunakan Metode DPPH. Proceeding Mulawarman Pharm Conf. 2022;15:165–70. doi.org/10.25026/mpc.v15i1.637
Koban IYR, Klau ME, Rame MMT. Chmk pharmaceutical scientific journal volume 2 nomor 2, september 2019. CHMK Pharm Sci J. 2019;2(2):62–72.
Umarudin, Susanti R, Yuniastuti A. Efektifitas ekstrak tanin seledri terhadap profil lipid tikus putih hiperkolesterolemi. Unnes J Life Sci. 2012;1(2):78–85.
Handayani FW, Muhtadi A, Farmasi F, Padjadjaran U, Dara T, Manis K, et al. Review Jurnal: Aktivitas Tanaman Jati Belanda (Guazuma ulmifolia Lamk.) Sebagai Antihiperlipidemia. Farmaka. 2020;17:1–15.
Harini M, Astirin OP. Kadar Kolesterol Darah Tikus Putih (Rattus norvegicus) Hiperkolesterolemik setelah Perlakuan VCO. Nusant Biosci. 2009;1:53–8.
CCL4. IEEJ Trans Power Energy. 2022;142(7):NL7_3-NL7_3. doi.org/10.1541/ieejpes.142.L7_1
Elsawy H, Badr GM, Sedky A, Abdallah BM, Alzahrani AM, Abdel-Moneim AM. Rutin ameliorates carbon tetrachloride (CCl4)-induced hepatorenal toxicity and hypogonadism in male rats. PeerJ [Internet]. 2019 [cited 2023 Aug 10];7. Available from: /pmc/articles/PMC6545103/. doi.org/10.7717/peerj.7011
Kamalakkannan N, Rukkumani R, Viswanathan P, Rajasekharan KN, Menon VP. Effect of curcumin and its analogue on lipids in carbon tetrachloride - Induced hepatotoxicity: A comparative study. Pharm Biol. 2005;43(5):460–6. doi.org/10.1080/13880200590963880
Purkins L, Love ER, Eve MD, Wooldridge CL, Cowan C, Smart TS, et al. The influence of diet upon liver function tests and serum lipids in healthy male volunteers resident in a Phase I unit. Br J Clin Pharmacol. 2004;57(2):199–208. doi.org/10.1046/j.1365-2125.2003.01969.x
Andari F, Rahayuni A. Pengaruh Pemberian Serbuk Biji Labu Kuning (Cucurbita moschata) Terhadap Penurunan Kolesterol Total Tikus Wistar Hiperkolesterolemia. J Nutr Coll. 2014;3(4):509–16. doi.org/10.14710/jnc.v3i4.6844
Rohmah BL. Identifikasi Senyawa Metabolit Sekunder Dan Uji Aktivitas Antioksidan Ekstrak Daun Sangket (Basilicum polystachyon L. Moench) Sebagai Bahan Dasar Pembuatan Selai. skripsi Walisongo State Islam Univ Semarang. 2021;1–119.
Nurmilatina. Analisis komposisi kimia daun kelakai (stenochlaena palustris Bedd.) dengan berbagai pelarut menggunakan GCMS. J Ris Ind Has Hutan. 2017;9(1):9–16. doi.org/10.24111/jrihh.v9i1.2952
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2024 Barigas: Jurnal Riset Mahasiswa
Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
